These photographs show how the problem has taken root on run-down buildings in the town's Market Square, with even a small tree growing from one chimney pot.
The unsightly vegetation is sprouting from the guttering of several key buildings in the town-centre, presenting a safety hazard as well as detracting from the town's image.
In response to the complaints from the public, the Tyrone Times is launching a 'stop the grot' campaign to tackle derelict and eyesore buildings in Dungannon and throughout the council borough.
UUP Councillor Walter Cuddy welcomed the initiative, saying that it was time residents 'got proud of their town'.
"We want everyone to take responsibility for the appearance of their surroundings, from teenagers and schoolchildren to parents and pensioners.
"Landlords, especially those who own derelict properties, have a duty to ensure their buildings are in a state of good repair and are not a health and safety hazard.
"If buildings are spruced up, given a lick of paint, and weeds removed from rooftops, the image of the town will be enhanced and people will want to spend more time here."
Councillor Cuddy, who owns Sloans Newsagency, revealed how the windows of his premises had been smashed during a vandalism attack a week ago.
"A lot of windows get broken by vandals, and if they are left unrepaired, it only encourages more vandalism.
"If you let standards drop then anti-social behaviour increases.
"We can all make a start by not throwing litter around.
"It's our town and we need to look after it."
If you spot a dilapidated building or an area that is being used as a dumping ground that needs cleaning up, contact our office and let us know.
We'll be out as quick as a flash to get a picture of the evidence.
You can also give us details of any unsightly areas by leaving your comments on this story by emailing anthony.quinn@jpress.co.uk