Four people have been arrested and a quantity of drugs seized in Coalisland.
The search on Tuesday, uncovered 1.7kg of class B drug mephedrone.
Police also seized 1,000 of cash under proceeds of crime legislation.
The drug had estimated street value of 51,000.
Three men and one woman were arrested in connection with the raid on suspicion of drugs offences.
They have since been bailed pending forensic tests.
The seizure has been welcomed by Inspector Gerry McGrath.
He stated the seizure had taken 'dangerous drugs off the streets of Dungannon and Cookstown.'
Ulster Unionist Assembly member Billy Armstrong welcomed the development, stating it is a "great relief to all the law abiding people in the area.
The threat posed by such illegal drugs affects every section of our society" he went on.
Mephedrone was banned in April of this year having been reclassified as Class B.
The drug had been sold in shops legally as plant food as was considered to be a 'legal high'.